Defining endotypes in infant bronchiolitis: the first step toward personalised treatment
Associate Professor Dani Dixon
Bronchiolitis is the most common severe respiratory tract illness in infants and remains the dominant cause of infant hospitalisation. There is no specific treatment apart from respiratory support as disease mechanisms are unknown. Bronchiolitis is predominantly caused by viral infections that induce an immune response which varies between patients. We, and others, have found measurable biomarkers associated variably with severity, length and chronic morbidity of bronchiolitis. By modelling clinical characteristics with combinations of these biomarkers we aim to be able to identify representative cohorts (endotypes) of bronchiolitis as a first step toward personalised treatment regimens, enhancing individual care and recovery.