A novel intervention strategy to prevent IUGR
Dr Kathryn Gatford
The University of Adelaide
Intrauterine growth restriction (IUGR) increases risks of perinatal death >5-fold, and has lifelong adverse effects on health. There is currently no treatment to prevent or cure IUGR. We wish to test a novel approach to stimulate the mother’s own production of hormones that promote placental function and fetal growth. We are requesting support to test active ghrelin treatment in mice with variable litter size and prenatal constraint. Importantly, diet can be used to induce activation of ghrelin, providing a pathway for developing a therapy to prevent IUGR which is acceptable to patients.