A therapeutic for infant acute lung injury: minimising immune-mediated damage to developing lungs during respiratory infection
Miss Elena Cavallaro
Bronchiolitis and pneumonia are leading causes of infant hospitalisation in Australia. The exaggerated immunological insult stemming from these infections on developing lungs is associated with early-childhood asthma development. We have used a small protein, feG, to reduce the consequences of acute lung injury in various adult animal models, by dampening the immune response. We aim to assess feG efficacy in reducing the short and long-term effects of bronchiolitis and pneumonia during infancy, where feG may be an ideal candidate for returning the balance of the immune response in the airways.