Characterization of beta cell-like cells coverted from human urine stem cells
Professor Xin-Fu Zhou
University of South Australia
Type 1 diabetes (T1D) is a life-long condition usually diagnosed in childhood. The desired therapy for T1D is to replenish the lost beta cells with functional healthy beta cells. Islet replacement therapy is a possible attractive solution and the success with clinical islet transplantation demonstrates the general approach has the potential to restore normal glucose control in T1D patients. In this project, we propose a novel approach to address the problem of low availability of islets for replacement therapy and the immune mediated rejection response by using patients own stem cells.