Project title:

Developing a new therapeutic for childhood acute myeloid leukaemia (ECR)

Chief Investigator:

Dr Mingfeng Yu

Funding Amount:

$ 35,000

Recipient:

University of South Australia

Overview:

In Australia, acute myeloid leukaemia (AML) is the second leading cause of cancer death in children. Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are the most frequent genetic alterations in AML, and are associated with poor prognosis. Thus, FLT3 has emerged as a therapeutic target for treating AML. We have recently identified a highly potent FLT3 inhibitor that displays a selectivity for this kinase superior to known FLT3 inhibitors under development. This project will further evaluate the anti-cancer efficacy of this inhibitor in animal models of AML, and a successful outcome will support its advancement for treating childhood AML.

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