Project title:

Implication of BRCA1/2 germline variants for childhood AML biology and treatment.

Chief Investigator:

Professor Richard D’Andrea

Funding Amount:



University of South Australia


We have uncovered a novel mechanism associated with development of childhood AML, an aggressive childhood malignancy. Our studies suggest that a significant percentage of childhood AML patients will benefit from tailored therapy with approved clinical agents. To test this we propose a number of experiments using AML patient samples.

Review Research Outcomes

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