Injury site-derived proteoglycan glypican-3 suppresses growth plate cartilage bony repair and bone fracture healing
Dr Yu-Wen Su
University of South Australia
Two major challenges in paediatric orthopaedics are (1) the faulty or unwanted bony repair of injured growth plate and (2) failure and/or delay in bone fracture healing, which cause high morbidities and burden. Our recent data suggest that injury site-derived proteoglycan glypican-3 suppresses growth plate bony repair and bone healing. Using a rat model of growth plate repair and bone healing, the proposed work will reveal functions and action mechanism of glypican-3 in growth plate repair and bone healing, and define if glypican-3 can serve as a target for developing strategies blocking growth plate faulty repair and enhancing bone healing.