Chimeric Antigen Receptor Tregulatory cells (CAR-Treg) as a treatment for Type 1 Diabetes (TID)
Dr Timothy Sadlon
Women’s and Children’s Health Network
Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing pancreatic beta-cells. There is no cure for T1D, and patients require lifelong daily insulin injections. In T1D, Regulatory T cells (Tregs) fail and can no longer prevent the autoimmune response. Giving Tregs to T1D children is a potential new therapy but has been hampered by an inability to make large numbers of the ‘right’ Treg that will work in the pancreas. We propose to overcome this by reprogramming Treg with autoantigen targeting chimeric antigen receptors to test their suitability as a new T1D therapy.