Project title:

Directed differentiation of embryonic stem cells  to insulin producing cells as a cure for Type 1 diabetes

Chief Investigator:

Associate Professor Mark Nottle

Funding Amount:



The University of Adelaide


The directed differentiation of human embryonic stem cells to insulin producing cells is seen as a cure for Type I diabetes. However human ESCs are not the same as those originally isolated in mice which has led to the suggestion that these may not be the best cell type for this therapy. We have developed a method which allows us to isolate ESCs similar to that originally isolated  in mice. In characterising these cells we have shown that these can be directed to differentiate to insulin producing cells. The aim of the present study is to complete the characterization of these cells.

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