Investigating causes of congenital heart disease using a mouse model with great artery and cardiac outflow tract defects
Dr Sophie Wiszniak
University of South Australia
Eight babies are born with a heart defect everyday in Australia, which equates to 1% of all births, and is the leading cause of infant mortality and morbidity. We have recently discovered cardiac outflow tract, great artery, arterial valve and ventricular septum defects in Nedd4 knockout mice, which are reminiscent of the congenital heart defects seen in children. This mouse model will help us to understand the mechanistic processes controlling heart development, with the aim to improve diagnosis and provide new therapies for these highly prevalent disorders.