Investigating the relationship between the ABO blood group system and Shigella interaction with cells
Dr Elizabeth Ngoc Hoa Tran
The University of Adelaide
Shigella is the leading cause of bacillary dysentery, a human inflammatory disease of the intestines that causes severe diarrhoea in children under the age of 5. Sugar structures (LPS O antigens) on Shigella’s surface have recently been shown to adhere directly to ABO blood group sugars on gut cells. This project will investigate the relationship between ABO blood groups and the adherence/invasion of different Shigella strains to cells, potentially determining if children of a certain blood type are more susceptible to infection, and providing informed approaches to vaccine developments.