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Studies into the mechanisms that progress protracted bacterial bronchitis to bronchiectasis in children, and therapeutic targeting of these processes
Professor Sandra Hodge
Inadequate diagnosis and treatment of recurrent Protracted Bacterial Bronchitis (PBB) may lead to reduced lung function and lower life-expectancy. We have found defective airway macrophage phagocytic function in these children that may contribute to a progression of PBB to bronchiectasis. We also found that the macrophage dysfunction in adults with chronic lung disease is associated with sphingosine signalling and that this system is a therapeutic target for FTY720 and macrolide antibiotics. Translating this data to the paediatric setting has a high likelihood of identifying new therapies.