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T-follicular helper cells in children with malaria
Dr Michelle Boyle
Menzies School of Health Research
Malaria caused by Plasmodium results ~ 500,000 deaths annually, the majority children under five years of age. Antibodies are important in immunity against malaria. Specific cells called T-follicular helper cells (TfH) are essential for antibody development. Malaria in children may disrupt TfH cells, but whether this occurs in all forms of malaria and in both children and adults, and the outcomes for antibody development is unknown. We will investigate TfH cells in two forms of malaria and study the impact of TfH on antibody responses. Results will inform the development of vaccines.