Impact of Phthalate exposure in fathers on programming of offspring neurological phenotype

Chief Investigator:

Professor Sarah Robertson

Funding Amount:



University of Adelaide


Autism spectrum disorder (ASD) is a complex developmental disorder which effects 1:100 Australians. It is accepted that unknown environmental factors contribute to ASD risk, with studies linking changes in the gametes and conception environment to increased risk. There is speculation that endocrine disrupting compound (EDC) exposure contributes to ASD. Animal models indicate that maternal preconception EDC exposure alters offspring brain development, but few studies evaluate paternal EDC exposure, despite epidemiological data linking male pre-conception EDC exposure to poor childhood health.

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