Investigating proof-of-concept for genetic therapy of PCDH19-Clustering Epilepsy using preclinical mouse models.
Chief Investigator: Prof Paul Thomas
Funding Amount: $99,988
Recipient: The University of Adelaide
Overview: This project investigates the potential rescue of PCDH19-Clustering Epilepsy neuropathology through annulment of Pcdh19 in the brain. Using our unique pre-clinical models and novel adeno-associated virus vectors, we will identify when pathological changes first occur in the brain and determine the potential efficacy of genetic therapy in counteracting this pathology.