Investigations into sepsis-induced high-mobility group box 1 (HMGB1) and effects on neurodevelopment in survivors of neonatal sepsis
Dr Kerrilyn Diener
The University of Adelaide
Preterm babies are particularly vulnerable to acquiring sepsis during their hospital stay, which not only increases the risk of mortality, but also the likelihood of brain-related disorders in survivors from 28% to 49%. There is an emerging concept that HMGB1, a danger molecule released within the body as a result of sepsis, can perpetuate this abnormal brain development. We will investigate this further, as our aim is to develop a targeted therapy that will increase survival rates and support normal brain development. This will significantly benefit the long-term health for preterm neonates.