Targeting regulatory T cells to protect against preterm birth
Chief Investigator: Dr Ella Green [Early Career Researcher]
Funding Amount: $39,775
Recipient: The University of Adelaide
Preterm birth (PTB) is the leading cause of neonatal mortality, and preterm infants have an increased lifetime risk of developmental disorders (Cerebral Palsy, ADHD, ASD) and metabolic disorders (obesity, cardiovascular disease). As 8.7% of Australian babies are born preterm each year, it is imperative to understand biological mechanisms underpinning PTB and identify modifiable targets to develop interventions to alleviate this pregnancy complication. PTB is characterised by inflammation and is linked to dysfunction in the maternal immune system. This research will investigate the mechanisms by which immune cells called T cells have a causal role in the pathogenesis of preterm birth.