Testing combined therapies as a powerful tool for controlling paediatric Glioblastoma multiforme invasiveness.

Testing combined therapies as a powerful tool for controlling paediatric Glioblastoma multiforme invasiveness.

Chief Investigator: Dr Sunita Ramesh

Funding Amount : $91,816

Recipient: Flinders University

Overview: Glioblastoma multiforme (GBM) is a common cause of cancer-related deaths in children. Current treatments focus on disrupting single signalling pathways to halt disease progression. Our pilot data with GBM cell lines (adult) and spheroids suggest selected combinations of channel inhibitors targeting multiple pathways, at low doses (no cytotoxicity) slow invasiveness more powerfully than single agents. We propose to evaluate these blocker combinations for controlling invasiveness in paediatric GBM cell lines and tissue explants. Outcomes are essential for developing new combination therapies for limiting GBM invasiveness while minimising collateral damage to healthy neurons and glial cells in the central nervous system.